Quinolines and derivatives

Ambeed Palladium II 2 2 2trifluoroac

Palladium(II) 2,2,2-trifluoroacetate, 42196-31-6, 98%

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Medchemexpress LLC Azido-PEG1-amine | 464190-91-8 | ≥98.0% | C4H10N4O | 100 MG

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Azido-PEG1-amine is a PEG-based PROTAC linker designed for the synthesis of PROTACs. It functions as a click chemistry reagent due to its Azide group, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules possessing DBCO or BCN groups. PROTACs utilize two ligands connected by a linker to target an E3 ubiquitin ligase and a protein of interest, facilitating selective degradation via the intracellular ubiquitin-proteasome system.

• PEG-based PROTAC linker
• Functions as a click chemistry reagent
• Enables copper-catalyzed azide-alkyne cycloaddition (CuAAc)
• Participates in strain-promoted alkyne-azide cycloaddition (SPAAC)
• Utilized in PROTAC synthesis
• Relevant for cancer targeted therapy

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Medchemexpress LLC 5'-O-(4,4'-dimethoxytrityl)-2'-O-methyluridine | 103285-22-9 | 98.0% | 560.59 g/mol | C31H32N2O8 | 1 ML

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5'-O-(4,4'-Dimethoxytrityl)-2'-O-methyluridine is a protected 2'-O-methyluridine nucleoside used as a building block in oligonucleotide synthesis and nucleoside chemistry. It is supplied as a light yellow solid and as a 10 mM solution in DMSO for laboratory research applications.

• Protected 2'-O-methyl uridine analog for oligonucleotide synthesis.
• Available as a light yellow solid and as a 10 mM solution in DMSO.
• Purity 98.0% (data sheet).
• Molecular formula C31H32N2O8; molecular weight 560.59 g/mol.
• Supplied in multiple solid sizes for scale flexibility.

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Ambeed 4 4 6Dimethoxy1 3 5triazin2yl

4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholin-4-ium tetrafluoroborate, 293311-03-2, 95%

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Ambeed 1 2 3 4Tetrahydroquinoline

1,2,3,4-Tetrahydroquinoline, 635-46-1, 98%

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Ambeed 5Amino2methoxypyrimidine

5-Amino-2-methoxypyrimidine, 56621-89-7, 98%

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Ambeed Palladium II 2 2 2trifluoroac

Palladium(II) 2,2,2-trifluoroacetate, 42196-31-6, 98%

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Ambeed 3 4Chlorophenyl N pyridin4ylme

3-(4-Chlorophenyl)-N-(pyridin-4-ylmethyl)adamantane-1-carboxamide, 915385-81-8, 98%

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Ambeed R 4Benzyl2oxazolidinone

(R)-4-Benzyl-2-oxazolidinone, 102029-44-7, 98%

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Medchemexpress LLC DBCO-PEG9-amine | 2353409-99-9 | 95.0% | C39H57N3O11 | 25 MG

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DBCO-PEG9-amine is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. This compound functions as a click chemistry reagent, containing a DBCO group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules possessing Azide groups. PROTACs themselves consist of two different ligands connected by a linker; one ligand targets an E3 ubiquitin ligase, and the other targets the protein intended for degradation. They operate by exploiting the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

• PEG-based PROTAC linker
• Utilized in the synthesis of PROTACs
• Functions as a click chemistry reagent
• Contains a DBCO group for SPAAC reactions
• Facilitates strain-promoted alkyne-azide cycloaddition with azide groups
• Exploits the intracellular ubiquitin-proteasome system
• Selectively degrades target proteins

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Medchemexpress LLC MCC950 | 210826-40-7 | 99.8% | 200 MG

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MCC950 is a potent and selective NLRP3 inhibitor, with IC50s of 7.5 and 8.1 nM in BMDMs and HMDMs. It blocks canonical and non-canonical NLRP3 activation at nanomolar concentrations. This product is for research use only.

• Potent and selective NLRP3 inhibitor
• Blocks canonical and non-canonical NLRP3 activation
• Specifically inhibits NLRP3, not AIM2, NLRC4, or NLRP1
• Reduces interleukin-1β (IL-1β) production
• Attenuates the severity of experimental autoimmune encephalomyelitis (EAE)

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TARGETMOL CHEMICALS INC KRM-III 5MG

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Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. KRM-III is an orally active T cell antigen receptor (TCR) inhibitor with anti-inflammatory activity that potently inhibits TCR and myristate acetate/fosfomycin/ionomycin-induced NFAT nuclear factor activation and T cell proliferation with an IC50 of approximately 5 uM. purity: 99%

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